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狂饮成为卒中的独立危险因素   

2008-10-11 14:34:16|  分类: 營養健康 |  标签: |举报 |字号 订阅

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http://stroke.ahajournals.org/cgi/content/abstract/STROKEAHA.108.520817v1

Increased Stroke Risk Is Related to a Binge Drinking Habit
Laura Sundell MD*; Veikko Salomaa MD, PhD; Erkki Vartiainen MD, PhD; Kari Poikolainen MD, PhD; and Tiina Laatikainen MD, PhD
From the Department of Health Promotion and Chronic Disease Prevention (L.S., V.S., E.V., T.L.), National Public Health Institute (KTL), Helsinki; the University of Kuopio (L.S.), Kuopio; and the Finnish Foundation for Alcohol Studies and Department of Mental Health and Alcohol Research (K.P.), National Public Health Institute (KTL), Helsinki, Finland.

* To whom correspondence should be addressed. E-mail: laura.sundell@ktl.fi.

Background and Purpose—Heavy alcohol consumption increases the risk for all strokes, whereas moderate regular alcohol consumption is associated with a lower risk for ischemic stroke. The purpose of this study was to evaluate the effect of different drinking patterns on stroke risk, independent of average alcohol intake.

Methods—A prospective cohort study of 15 965 Finnish men and women age 25 to 64 years who participated in a national risk factor survey and had no history of stroke at baseline were followed up for a 10-year period. The first stroke event during follow-up served as the outcome of interest (N=249 strokes). A binge drinking pattern was defined as consuming 6 or more drinks of the same alcoholic beverage in men or 4 or more drinks in women in 1 session. Cox proportional-hazards models were adjusted for average alcohol consumption, age, sex, hypertension, smoking, diabetes, body mass index, educational status, study area, study year, and history of myocardial infarction.

Results—Binge drinking was an independent risk factor for total and ischemic strokes. Compared with non–binge drinkers, the hazard ratio for total strokes among binge drinkers was 1.85 (95% CI, 1.35 to 2.54) after adjusting for average alcohol consumption, age, and sex; the association was diluted after adjustment for other risk factors. Compared with non–binge drinkers, the risk for ischemic stroke was 1.99 (95% CI, 1.39 to 2.87) among binge drinkers; the association remained statistically significant after adjustment for potential confounders.

Conclusions—This study found that a pattern of binge drinking is an independent risk factor for all strokes and ischemic stroke.

丁香园编译:
狂饮成为卒中独立危险因素

狂饮恶习增加卒中危险

劳拉.桑德尔MD. ,维克.撒诺玛MD. PhD. ; 埃尔基.瓦尔蒂爱宁 MD, PhD; 卡莉.波依科莱宁 MD, PhD; 和蒂娜.拉蒂凯宁 MD, PhD

赫尔辛基国立公共卫生研究所(KTL)健康促进与慢性病预防部门(劳拉.桑德尔,维克.撒诺玛,埃尔基.瓦尔蒂爱宁,蒂娜.拉蒂凯宁);赫尔辛基Kuopio大学(劳拉.桑德尔);芬兰酒精研究基金会和赫尔辛基国立公共卫生研究所(KTL)饮酒与精神健康研究部门。

*通信请与如下E-mail联系:laura.sundell@ktl.fi.

背景与目的—大量饮酒增加了各类卒中的发病危险,而规律性中度饮酒则有助于降低缺血性卒中的发病率。该研究的目的是,在排除了平均酒精摄入量对卒中的影响后,评估不同的饮酒方式对于卒中发生风险的影响。

方法—该研究是一项前瞻性队列研究,它从一项全国性卒中危险因素调查的参与者中选取了15965名25到64岁没有卒中史的芬兰男性和女性,依此建立了基线水平,并对他(她)们进行了为期十年的随访研究。在随访中首次出现的卒中事件被视作结局事件。(N=249 卒中)狂欢式的饮酒被定义为在某一场合下男性摄入6倍或者更多的酒精饮料,或者是女性摄入4倍或者更多的酒精饮料。该研究将Cox比列风险模型用平均酒精摄入量,年龄,性别,高血压,吸烟,糖尿病,体重指数,受教育程度,研究领域,研究时间和心肌梗死史等因素进行了校正。

结果—狂饮对于卒中总发病率和缺血性卒中发病率都是独立的危险因素。和那些不狂饮的人相比,在狂饮者中总卒中相对危险比为1.85(95%置信区间,1.35—2.54 ),在对其它危险因素诸如平均酒精摄入量,年龄,性别都进行了校正之后,这种狂饮与卒中的相关性被削弱了。和不狂饮的人相比,狂饮者缺血性卒中的相对危险度是1.99(95%置信区间,1.39—2.87);在对潜在的各种混杂因素进行了校正之后,该关联依然具有明显的统计学意义。

结论—该研究发现,狂饮是卒中和缺血性卒中的独立危险因素。

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