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肥胖可能降低男性生育能力   

2008-10-11 14:55:00|  分类: 營養健康 |  标签: |举报 |字号 订阅

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Obesity may diminish a man's fertility

NEW YORK (Reuters Health) - Being obese may dim a man's chances of becoming a father, even if he is otherwise healthy, a new study suggests.

Researchers found that among 87 healthy men ages 19 to 48, those who were obese were less likely to have ever fathered a child. More importantly, they showed hormonal differences that point to a reduced reproductive capacity, the researchers report in the journal Fertility and Sterility.

Compared with their thinner counterparts, obese men had lower levels of testosterone in their blood, as well as lower levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) -- both essential to reproduction.

According to the researchers, these relatively low levels of LH and FSH are suggestive of a "partial" hypogonadotropic hypogonadism. This is a condition in which the testes do not function properly due to signaling problems in the hypothalamus or pituitary gland, two brain structures involved in hormone secretion.

The findings suggest that obesity alone is an "infertility factor" in otherwise healthy men, write Dr. Eric M. Pauli and his colleagues at the Pennsylvania State University College of Medicine in Hershey.

Of the 87 men in the study, 68 percent had had a child. Pauli's team found that the average body mass index, or BMI, was lower among these men compared with those who'd never fathered a child; in the former group, the average BMI was 28, which falls into the range for "overweight," while the average BMI for childless men was nearly 32, which falls into the "obese" range.

When the researchers assessed the men for several reproductive hormones, they found that the more obese a man was, the lower was his LH and FSH levels. On the other hand, increasing obesity correlated with increasing estrogen levels.

Excess body fat, Pauli's team explains, may increase the conversion of testosterone to estrogen in a man's blood. Such hormone alterations could, in turn, signal the brain to suppress FSH and LH production.

Past studies have linked obesity with a dampened libido and increased risk of erectile dysfunction, the researchers note. Those effects, they say, along with the hormonal alterations seen in this study, could act together to decrease an obese man's fertility.

SOURCE: Fertility and Sterility, August 2008.
丁香园编译:
肥胖症可能降低男性的生育能力

纽约(路透社 健康)-一项新报告指出:肥胖男士成为父亲的机会可能不高,即使他其他方面健康。

研究人员在Fertility and Sterility中报道说,在他们调查的87个,年龄在19到48随范围内的健康男性中,发现那些肥胖的男性不容易成为孩子的父亲。更重要的是,肥胖男性显示出荷尔蒙的不同,这些差别可以表明生育能力的降低。

和瘦的受试者相比,肥胖男性血液中的睾酮水平较低,同时促黄体激素(LH)和促卵泡激素(FSH)的水平也较低,这两种激素对生育至关重要。

据研究表明,那些相关的低水平的LH和FSH提示“局部”的低促性腺素性功能减退症。这种情况是由于能调节激素分泌的下丘脑或者脑垂体发出信号的问题,结果导致睾丸功能绪乱。

研究发现在仅有肥胖症而其他方面的男性中,肥胖症是一个单独“不孕因素”,宾夕法尼亚大学医学部的Dr. Eric M. Pauli和他的同事这样写道

在被调查的87个人中,有68%的人有孩子。Pauli的小组发现那些有孩子的人的体重指数或者BMI比那些没有还是的人低。在有孩子的人这组BMI的平均值是28,这个数值是到了超重的范围。而没有孩子的人这组指数接近32,到了肥胖的范围。

当研究者评估几项生殖性的荷尔蒙发现:越是肥胖的男人,其LH和FSH的水平就越低。换句话说,逐渐肥胖和雌激素水平的升高有关。

Pauli的小组这样解释:过多的体内脂肪可以增加男性血液中睾丸酮向雌激素的转换。这样荷尔蒙的改变可能依次的向大脑发信号,来抑制FSH和LH的产生。

研究人员指出,过去的研究已把肥胖联系到迟缓的性欲和增高的勃起无力的可能。这些效应和荷尔蒙改变一起纳入研究发现,他们可以共同来减少肥胖男性的生育,研究人员表示。

来源:Fertility and Sterility,2008年八月


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